Marcquise Reed sat out again, but this time Shelton Mitchell and the rest of the Clemson team took care of things in his stead.
Mitchell scored 20 points to lead the Tigers, picking up the slack on the backcourt scoring typically headlined by Reed.
David Skara pitched in 16 points, while Elijah Thomas added 15 points and 9 rebounds despite spending much of the game in foul trouble.
The game was tightly contested throughout the first half, with Clemson taking a 31-30 lead into the break. The Tigers scored the first basket of the second half, but a subsequent 10-0 run by the Highlanders gave them a 40-33 lead.
Clemson answered with a quick 8-0 run of its own to regain the lead, and the game was a back-and-forth affair for the next nine minutes, with Ed Polite Jr.’s jumper tying the game at 58 with just over five minutes to play.
The Tigers scored the next two baskets, however, and led the rest of the way en route to a 74-66 win.
Clyde Trapp had his share of struggles in the game but played well down the stretch and finished with 11 points starting in place of Reed.
Polite Jr. scored 16 points for Radford, while Carlik Jones paced the Highlanders with 18.
The Tigers return to action Tuesday night against Charleston Southern.