Clemson overcame a sluggish first half and trailed Notre Dame by just three points, 50-47, with just over 10 minutes to play.
But as Donte Grantham attacked on a one-on-one fast break, the Irish's Steve Vasturia slid under Grantham and was rewarded with a charge call. The Irish quickly went on an 8-2 run and never looked back, leading by as many as 13 in the final minutes before the Tigers closed the final tally to 89-83.
Clemson shot better than 52% from the field and made 10 of its 20 three-point attempts, but Notre Dame was nearly as efficient and converted 21 of 25 free throws — where they refused to give ground as the Tigers tried to mount a late comeback.
Jaron Blossomgame scored a career-high 30 points for the Tigers, but Notre Dame's balanced offensive attack was too much as the Irish had all five starters score in double figures.
Zach Auguste led the way for Notre Dame with 19 points and clearly outplayed Clemson centers Landry Nnoko and Sidy Djitte, who combined for just five points.
Demetrius Jackson and V.J. Beachem added 17 and 15 points, respectively, for the Irish.
Avry Holmes scored 17 and Donte Grantham 15 for the Tigers, but they couldn't keep up with the Notre Dame, which made five threes in the final 10 minutes.