Jaron Blossomgame scored 17 points and Avry Holmes added 16 to lead Clemson to an upset win over No. 16 Louisville.
Holmes made 11 of 14 free throw attempts, including a pair in the final seconds to seal the win for the Tigers. Clemson went 32 of 44 from the line as a team.
Donte Grantham and Jordan Roper chipped in 12 and 10 points, respectively, and Sidy Djitte posted 9 points and 12 rebounds off the bench.
The Tigers held Louisville leading scorer Damion Lee to 6 points on 2 of 12 shooting, while backcourt mate Trey Lewis made just 3 of 19 shots.
The Cardinals finished just 3 of 23 from beyond the arc after missing their first 15 attempts.
After a disappointing 7-5 performance in non-conference play and a loss to open the conference slate, Clemson has won three ACC games in a row. The Tigers host No. 14 Duke on Wednesday.