Quinn Cook 27 had points and Justice Winslow 20 for No. 4 Duke in a 78-56 win over Clemson.
Clemson played well early and led 15-13 with 10 minutes left, but the Blue Devils closed the first half on a 29-12 run to lead at the half 42-27.
After trailing by as many as 19 early in the second half, the Tigers trimmed the lead to 10 on a Damarcus Harrison jumper with 14 minutes to play. But Duke put together a 10-0 from there to end any hopes Clemson may have had of a comeback.
Duke's star center Jahlil Okafor didn't play with an ankle injury, but the Blue Devils didn't need him. They forced Clemson into 14 turnovers and shot better than 50 percent from the field in the rout. Clemson shot 41.5 percent from the floor and just 4 of 18 from three-point range.
Jaron Blossomgame led the Tigers with 10 points, but no player could find much of a groove on offense for Clemson.
Tyus Jones and Grayson Allen both scored in double figures for the Bule Devils, with 11 and 10 respectively.
Clemson has week off before taking on Georgia Tech at home next Saturday.