Clemson held Louisville to just 14 first half points en route to a 77-62 win.
The Tigers are a dangerous spoiler.
A young Tiger team will embark on the Road to Omaha with a three game set against Liberty.
The Tigers nearly erased a 12-point halftime deficit but ultimately came up short against the Cavaliers.
The Tigers edged the Demon Deacons 74-71 in Littlejohn last week.
The Tigers fell down by 10-points in the second half, but Tevin Mack and Clyde Trapp scored 34 of Clemson’s 38 second half points to lead a come from behind victory.
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The grass is greenest in Clemson. Don’t leave.
Hunter Tyson scored a career-high 21-points as the Tigers took the lead with 5:46 remaining and held on despite several hiccups at the foul line.