Neutral site games are on the rise. There were 5 neutral site games involving BCS teams in 2011, and 7 in 2012; 8 are scheduled for 2013, 9 more for 2014... so the trend is there. Since 2008, Va Tech has schedule 6 home, 5 away and 1 neutral site game pretty much every year. Notre Dame is another team that schedules that way.
Of course Clemson has played an occasional neutral site game - in the Chick-Fil-A Kickoff game, in Atlanta. But not since the Temple game has Clemson played in Charlotte, NC. Meanwhile, the SC Gamecocks have played there and are scheduled to play there again. Admittedly, Columbia is a little closer to Charlotte than Clemson is, and Atlanta is a little closer to Clemson than Charlotte is... but y'all can't just let the chickens slowly take over one of the richest recruiting territories around! Charlotte has thousands of high school football players. SC wants 'em.
VT has played there before, but since the Hokies already play at least one or two games per year in NC (and Charlotte is on the opposite side of the state from VA), there doesn't seem to be much interest in playing there for VT. We tend to play our neutral site games in Washington, DC at Fedex Field (really Landover, MD).
I did some research on the whole neutral site game phenomenon, which I posted on my football blog if you are interested: Rx: Neutral site games. Also, I'd be very interested in what y'all have to say about playing a regular season game in Charlotte - let's say a "one and done" vs. a BCS team. What do you think?