This challenge is going to be difficult to predict with 7 out of 12 ACC coaches either in their first or second year on the job. That being said, I'll take an early swing at it (winning team in bold).
Miami at Purdue - Miami has a lot coming back, but Purdue is very tough to beat at home.
Northwestern at Georgia Tech - Georgia Tech will be playing an hour from campus with a depleted roster.
Illinois at Maryland - Illinois lost a lot, but Brandon Paul and D.J. Richardson are a better 1-2 punch than anything Maryland has.
Michigan at Virginia - UVA returns a lot and gets Mike Scott back. Michigan lost their best player.
Clemson at Iowa - Call me a homer, but Clemson has more talent and Iowa is still rebuilding.
Duke at Ohio State - Duke doesn't have a PG and their best player is a freshman. In an early season game, advantage OSU.
Indiana at North Carolina State - These teams have comparable talent, so advantage home team.
Penn State at Boston College - BC lost EVERYTHING, but bring in a solid class. PSU lost Talor Battle.
Florida State at Michigan State - On paper these teams are very close, but I'll take Izzo at home.
Virginia Tech at Minnesota - Always pick against VT in meaningful non-conference games.
Wake Forest at Nebraska - Wake is a train wreck.
Wisconsin at North Carolina. - Great matchup of contrasting styles. I expect Wisc to frustrate UNC with their pace for awhile.
Big 10 - 7
ACC - 5